4 edition of Cardiac electrophysiology and pharmacology of adenosine and ATP found in the catalog.
Includes bibliographies and index.
|Statement||editors, Amir Pelleg, Eric L. Michelson, Leonard S. Dreifus.|
|Series||Progress in clinical and biological research ;, v. 230|
|Contributions||Pelleg, Amir., Michelson, Eric L., Dreifus, Leonard S.|
|LC Classifications||RC685.A65 A2 1985|
|The Physical Object|
|Pagination||xvii, 395 p. :|
|Number of Pages||395|
|LC Control Number||86027671|
The macula densa is the thickening where the distal tubule touches the glomerulus. Although purinergic signaling has been connected to pathological processes in the context of neuron-glia communication, it has been revealed, that this is also very important under physiological conditions. The presence or absence of intrinsic sympathetic activity can slightly modify these effects, as can concurrent therapy with an -AR antagonist. The ability to express a cloned receptor gene in a cell previously not containing the receptor enables a researcher to study individual receptor subtypes and analyze their signal transduction properties.
In the physiology of the kidney, tubuloglomerular feedback TGF is a feedback system inside the kidneys. Procainamide, an antiarrhythmic agent that can be used to treat digitalis toxicity, also has the potential in the presence of disturbances of AV conduction to cause asystole or ventricular fibrillation. A rapid-acting -AR antagonist with a short half-life, esmolol, is now available intravenously. For more information, please see Dr. Three general clinical effects are apparent with calcium antagonists. It has an excitatory effect on neurones, and acts as a mediator in neuronal— glial communications.
Other concurrent diseases, such as chronic renal failure and diabetes mellitus, often require additional medication. However, due to the recent cloning and expression of receptors for ATP and adenosine, novel compounds have been developed with unique therapeutic potential for the treatment of thrombosis, stroke, epilepsy, chronic pain, immunological disorders, and cancer. Because the myocardial tissues most dependent on slow calcium currents include the sinoatrial and AV nodes, these regions are therefore most affected by calcium channel antagonists. As shown in Fig. Calcium channel antagonists, which are structural analogs of verapamil, such as D, D, fendiline, and prenylamine, also bind to 2-ARs but not 1-ARswhereas other structurally unrelated calcium channel blockers such as diltiazem and nifedipine do not bind to -ARs In microgliaP2X and P2Y receptors are expressed.
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These agents include phenylbutazone, phenobarbital, phenytoin, and rifampin. Clinically, hyperaemia in tissues manifest as erythema because of the engorgement of vessels with oxygenated blood.
The renin-angiotensin system is an important pathway in the maintenance of blood pressure via the pressor hormone angiotensin II 49, This suggests that failure of the LV promotes differential RV remodeling and potentially proarrhythmic chamber dyssynchrony.
Before the expiry of its patent, the P2Y12 receptor antagonist Clopidogrel trade name : Plavix was the second most prescribed drug in the world. Currently, there is no available treatment for SMA patients. General properties of calcium channels must be reviewed for a full understanding of this class of drugs.
Recent work in post-mortem hearts with familial BrS indeed found evidence for increased local levels of fibrosis and reduced levels of gap-junction proteins notably connexin in the RV outflow tract,61 supporting a role for region-specific structural abnormalities and conduction disturbances in BrS.
IPC has been studied extensively for the past 20 years and has resulted in the publication of more than 2, articles, which have significantly increased our understanding of the cellular mechanisms of ischemia and reperfusion injury.
Current and Planned Projects Investigating the effects of adenosine antagonists as potential treatments for diseases associated with excessive neuromuscular fatigue e. It involves the concept of purinergic signaling, in which an increased distal tubular sodium chloride concentration causes a basolateral release of adenosine from the macula densa cells.
J Pharmacol Exp Ther Jarvis The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years.
It can have medical implications but is also a regulatory response, allowing change in blood supply to different tissues through vasodilation. The goal is to identify potential molecular therapeutic targets that would delay or prevent drug resistance and relapse in AML and CML.
Because dihydropyridines have far fewer negative inotropic effects compared with verapamil and diltiazem, this class of calcium channel antagonists might theoretically be able to be used cautiously in patients with heart failure.
These processes are naturally modulated by local paracrine agents from endothelial cells e. Therefore, nitrate therapy should be continued perioperatively in patients already receiving these medications. In the kidney, the macula densa is an area of closely packed specialized cells lining the wall of the distal tubule, at the point where the thick ascending limb meets the distal convoluted tubule.
American Journal of Physiology. Although nitrate therapy is usually well tolerated, the most frequent side effects include dizziness, headaches, and postural hypotension. TPR depends on several factors, including the length of the vessel, the viscosity of blood determined by hematocrit and the diameter of the blood vessel.
The specific mechanisms to accomplish these effects vary from vasodilator to vasodilator. Because the half-life of most -AR antagonists in the early s was approximately 3 to 6 hours, holding the morning dose in effect resulted in almost no -AR antagonist concentration during surgery.
This makes the skin turn paler because less blood reaches the surface, reducing the radiation of heat. We will also create a hypomorphic allelic series of Smn mutations in mice. Mechanisms Underlying Left Ventricle versus Right Ventricle Differences The electrophysiological differences between the LV and RV can at least partially be attributed to the distinct embryological origin of the LV, arising from the first heart field, and the RV, arising from the second heart field.
Because reflex responses clearly influence the effect of calcium antagonists in the presence of an intact nervous system, the net response in humans is presented here whenever possible. Most recent evidence suggests that positive inotropic effects of digitalis glycosides result from altered excitation-contraction coupling.
Philadelphia, Pennsylvania: Elsevier Inc.Sep 25, · Thank you for writing this excellent book and for adding many years to my life. Antiarrhythmic drugs 1. Antiarrhythmic drugs 2. Electrophysiology of cardiac tissue • Impulse generation and transmission • Myocardial action potential •. Despite major improvements in the treatment of virtually all cardiac disorders, heart failure (HF) is an exception, in that its prevalence is rising, and only small prolongations in survival are occurring.
An increasing fraction, especially older women with diabetes, obesity, and atrial fibrillation exhibit HF with preserved systolic function. * Adenosine Receptor Subtypes: New Insights from Cloning andFunctional Studies * Modulators of Adenosine Uptake, Release, and Inactivation * Cardiac Electrophysiology of Adenosine: Antiarrhythmic andProarrhythmic Actions * Purinergic Modulation of Gastrointestinal Function * The Role of Adenosine in Asthma * ATP in Brain FunctionAuthor: Kenneth A.
Jacobson. With its unique, singular focus on the clinical aspect of cardiac arrhythmias, Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease makes it easy to apply today's most up-to-date guidelines for diagnosis and treatment.
An expert author team provides clear, clinically focused guidance on all types of cardiac arrhythmias, including practical techniques for. We determined the effects of the K-adenosine triphosphate (ATP)-blocking diuretic PNUA on plasma renin activity (PRA) in conscious and anesthetized atlasbowling.com conscious dogs, oral PNUA ( mg/kg) was less potent than hydrochlorothiazide ( mg/kg) and furosemide (FURO; mg/kg) but exhibited high natriuretic efficacy with little kaliuresis.
Purinergic signalling (or signaling: see American and British English differences) is a form of extracellular signalling mediated by purine nucleotides and nucleosides such as adenosine and atlasbowling.com involves the activation of purinergic receptors in the cell and/or in nearby cells, thereby regulating cellular functions.
The purinergic signalling complex of a cell is sometimes referred to as the.